Duderma

KEY INGREDIENT

• Dutasteride:  0.1% (1 mg in each ml).
  

TWO VERSIONS

We offer DuDerma in two versions. One is formulated with proplylene glycol (PG), the other is without PG (PG Free).

Both versions can be selected from the product Options (next to the product price).

If you are not sure whether you are allergic to PG, you can choose the regular DuDerma (~15% people are allergic to PG with symptoms such as itching scalp and skin rashes).

If you are allergic to PG, Duderma PG Free is the best topical dutasteride solution without minxidil for you.

Duderma is a dutasteride only product. We have other topical dutasteride products enhanced with minoxidil and/or finasteride (See details below).

MORE INFO 

Unit size: 60 ml (2oz). If you choose 60ml x 3, you will receive 3 units, each with 60 ml.

Concentration: 0.1% (1mg in each ml)

Each unit comes with a dropper.

If the concentration is too high for your usage, you can dilute DuDerma with the PG Solvent, or DuDerma PG Free with PG Free Solvent. If you mix one unit of Duderma with one unit of the Solvent, you will get 120 ml (4 oz) of 0.05% topical solution. To make a 0.025% topical dutasteride solution, you will add 20 ml of DuDerma to 60 ml of PG Solvent/PG Free Solvent.

INSTRUCTION

• Use up to 1 ml per application. Use no more than once  a day.
• Each unit is 60 ml (2 oz). The product comes with a calibrated dropper.
• One unit can last for at least 2 months.

ABOUT DUTASTERIDE

It is usually abbreviated as Dut in hair loss community. It is a type I and type II 5α-reductase inhibitor (Finasteride is a type II 5α-reductase inhibitor only) . 5α-reductase is an enzyme that converts testosterone to dihydrotestosterone (DHT). Excessive amount of DHT in the scalp is believed to be responsible for hair loss. The figure below shows how different products work for hair loss treatment. As shown, both finasteride and dutasteride work by inhibiting 5-alpha reductase, while other products such as RU58841,spironolactone, and ketoconazole work by preventing DHT from binding to hair follicles.

Literature:

• “A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dut-asteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia” Walter Gubelin Harcha et al. J Am Acad Dermatol. 2014 Mar. Link: https://pubmed.ncbi.nlm.nih.gov/24411083/

  Superiority of dut over finasteride in hair regrowth and reversal of miniaturization in men with androgenetic alopecia: A randomized controlled open-label, evaluator-blinded study Sujit J S Shanshanwal et al. Indian J Dermatol Venereol Leprol. Jan-Feb 2017. Link: https://pubmed.ncbi.nlm.nih.gov/27549867/

  Efficacy of  Oral and Duta-steride in the Treatment of Androgenetic Alopecia: A Systematic Review Maira Elizabeth Herz-Ruelas et al. Skin Appendage Disord. 2020 Nov. Link: https://pubmed.ncbi.nlm.nih.gov/33313048/

  “5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety” Rachita Dhurat et al. Dermatol Ther. 2020 May. Link: https://pubmed.ncbi.nlm.nih.gov/32279398/